He also added that Meghan is "a really kind and smart and intelligent young woman", describing her and her husband Prince Harry as a "really wonderful, loving couple".
Human rights lawyer Amal Clooney is to set up an award named the Amal Clooney Award, which is created to celebrate inspirational young women around the world.
The award, organised by youth charity Prince's Trust International, is meant to "highlight the work of young women who have succeeded against the odds to make a lasting difference in their communities", a spokesman said.
The "Oceans Eleven" actor, 57, addressed the press attention the Duchess of Sussex has received since she became a royal last May.
The Queen and Prince Charles release statements following New Zealand mosque attacks
Pope Francis assured "all New Zealanders, and in particular the Muslim community, of his heartfelt solidarity", the Vatican said. It is believed 49 people have been killed and at least 20 wounded in shootings at two mosques in Christchurch , New Zealand.
He said: "I think it's a little unfair at times".
Amal, who attended Oxford University, is an global and human rights barrister at Doughty Street Chambers.
"We've seen how that ends", he said.
The Prince's Trust was founded in 1976 by Prince Charles to help vulnerable youths aged between 11 to 30 get their lives back on track.
Nominees will be judge on how inspirational, impactful, sustainable, and life-changing their actions have been.
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