Messi's latest double takes his overall record for the season across all competitions to 36 goals in 35 appearances for Barca.
The Spanish champions jumped into an early lead in a series that was 0-0 after the first leg, when Messi converted a VAR-reviewed penalty with a cool chip.
Suarez then rounded Lyon goalkeeper Anthony Lopes to lay on a flawless pass for the unmarked Philippe Coutinho to nudge into an open net and double Barca's lead, although Lyon hauled themselves back into contention with a second-half strike from Lucas Tousart.
"The big stars add up to a lot", said Pique.
Messi bagged a brace, including a cheeky panenka penalty, and two assists as he bossed the game in typical fashion.
Marca reported that Suarez said in an interview with Movistar Plus: "I think I accidentally stepped on him (Denayer) and I think that unbalanced me a little".
The first clip shows him darting out to the right wing to prevent an attack before the ball ricochets off him and almost into the path of Luis Suarez. Instead, he just followed the ball and let it run through Marcelo's legs, at which point - we can safely assume - his soul went somewhere, anywhere, but not his body. We were able to recover the ball higher, posed problems and reduced the score.
The pair are level for Champions League hat-tricks with eight apiece, but it is significant that four of Ronaldo's have come in the knockout stages compared to only two of Messi's. "He is one of the best players of all time, a genius".
A worrying head injury to goalkeeper Anthony Lopes forced the visitors into a substitution just before halftime, with Mathieu Gorgelin taking over between the sticks.
Genesio said: "Antho (Lopes) had lost consciousness at the time but did not want to go out".
Sarah Sanders spars with CNN’s Jim Acosta over anti-Semitism allegations
The White House refused to voice "full confidence" in embattled Secretary of Labor Alex Acosta on Monday. Terri Sewell said on CNN shortly after Trump spoke.
- Tucker Carlson's Refusal to Apologize Is the 'Fox News Brand'
- Brazil elementary school shooting leaves 10 dead, 17 injured
- Kalank Teaser: A story of eternal love!
- Aaron Finch Praises Australia After "Unbelievable" Series Win Against India
- Judgment Removed From Sale in Japan After Actor Arrested
- Android Q Beta Ready for Pixel Phones
- 33% quota in jobs for women if we form govt: Rahul
- What they're saying about the Odell Beckham Jr
- Scientists signing petition over 'health dangers' associated with AirPods
- Fortnite's Latest Update Forces Xbox One and PS4 Users to Play Together