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World's first baby born via womb transplant from deceased donor

07 December 2018

The baby girl was born in Sao Paulo, Brazil, late a year ago following a successful 10 hour uterus transplant to a patient who had been born without a womb.

The mother was a 32-year-old woman with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome - a condition that causes female sexual reproductive organs, such as the uterus and vagina, to be underdeveloped or absent at birth.

Her uterus was removed and transplanted into the 32-year-old during a complex surgery that lasted 10 and a half hours.

Months later, the doctors implanted a fertilized egg that had been preserved in-vitro and in December 2017, a baby girl was delivered via C-section. In this case, a cesarean section was performed for birth at 35 weeks gestation, and along with the delivery of an nearly 6 pound healthy baby girl, the uterus was also removed.

While researchers in countries including Sweden and the USA have previously succeeded in transplanting wombs from living donors into women who have gone on to give birth, experts said the latest development was a significant advance.

He said live uterus donors are rare and typically eligible family members or close friends of women seeking the transplant.

There have been 39 womb transplants using a live donor, including mothers donating their womb to their daughter, resulting in 11 babies.

"The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population", Ejzenberg said in a statement about the results, describing the procedure as a "medical milestone". Ten previous attempts using deceased donors in the Czech Republic, Turkey and the us have failed.

The first childbirth following uterine transplantation from living donors occurred in Sweden in September 2013 and were also published in The Lancet.

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The whole field of uterus transplantation is in its early days.

She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised. Ten days later, doctors delivered the good news: she was pregnant. The team said the baby girl was healthy and developing normally.

Brazilian doctors are now planning more transplants following the procedure.

In the end, they held off an additional month after tests suggested the lining of the donor uterus wasn't quite thick enough to support implantation.

As with other organ recipients, the patient in this case was put on immune suppression drugs to reduce the chances of her body rejecting the transplant. The uterus is removed and immunosuppressants are stopped after birth, according to the Royal College of Obstetricians and Gynaecologists.

"It is a breakthrough in the field of obstetrics as well as a great advantage for women who lost their uterus for some reason or don't have from birth".

The world's first baby has been born via a uterus transplanted from a dead donor. Upon encountering a suitable candidate and donor, doctors must act quickly to remove the uterus and transport it to the patient. Uterine transplantation began in other countries where there are legal or ethical barriers to surrogacy-getting someone else to carry the pregnancy-O'Neill says.

Women who would be candidates for a uterus transplant would have absolute uterine infertility, meaning they don't have a uterus or that it is too damaged to support a pregnancy.

World's first baby born via womb transplant from deceased donor