Welbeck suffered the injury in the first half of the group stage fixture, with the score locked at 0-0.
He received oxygen and had his leg in a protective brace as he was taken off the pitch, with up to 10 medical staff around him as he received treatment.
The Arsenal forward's career has been plagued by injuries, and this could be the worst of the lot.
"He was working well and he was having a good match". "They are a big competitive team".
The 6-foot winger has been a revelation since leaving Angers for Lille in 2017, scoring 14 goals in all competitions last season before playing a starring role this term. You don't want it to happen but this is our profession.
"Now he is at the hospital".
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Emery said after the game: "Lichtsteiner's injury changed our idea on the match, we wanted to change for Eddie Nketiah and give another chance for the striker".
"We are very happy with Reiss". He's helped us with his behaviour, with his quality and his capacity. But I think the players were concentrated on the match and we forgot this injury the next minute on the pitch.
Some of his team-mates were also visibly affected by the incident.
The game only really opened up in the 88th minute when Jeremy Mathieu was shown a straight red for a foul on Pierre-Emerick Aubameyang as the striker raced through on goal.
He added: "Our mind is to be first in the group".
"After that they were concentrated on the game but asked about him at the end". "We will know [more] about his injury tomorrow".
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