The visitors needed just eight minutes to get their noses in front when, after Magpies goalkeeper Martin Dubravka had turned away an Eriksen shot, the Denmark worldwide delivered the resulting corner for defender Davinson Sanchez to attack.
Yedlin was helped off the pitch in added time and television cameras showed him being helped slowly through the tunnel by a member of Newcastle's medical staff.
Tottenham regained the lead in the 18th minute from another header, this one by Dele Alli, found at the back post by Serge Aurier's cross.
DF Davinson Sanchez, 7 - A lapse of concentration allowed Joselu a free header for Newcastle to equalise but, that apart, the Colombian global was solid and always quick to spot danger.
Speaking to Sky Sports News, Alli said that it was crucial that Spurs opened their Premier League campaign with a win.
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MF Moussa Sissoko, 7 - Assigned to the unglamorous role of breaking up the home team's rhythm, Sissoko stuck to his task.
One for the future in Luke Amos, perhaps; the 21-year-old made his Premier League debut, coming on for the final few minutes. Lucky not to pick up a second yellow card and Spurs looked more secure after he was substituted.
MF Lucas Moura, 6 - After a wonderful preseason, much was expected.
Davinson Sanchez (7/10): Grew into the game following an very bad start. Newcastle were mediocre in the first half, but looked like a risky side in the final 45 minutes. The ball crossed the line by 9mm. The telltale sign that all was not well, though, was in his hold-up play as many of his lay-offs were misplaced.
The Lilywhites managed to hold on to their lead despite a nervy second half that saw Newcastle hitting the bar twice while Kenedy missed a golden opportunity to level things up. Despite the rumours of a move during the transfer window, he looks committed to the cause.
They perhaps lacked a central focal point in midfield until Mousa Dembele was summoned from the bench with around 25 minutes to play and Eric Dier still remains an awkward fit in that position from which Pochettino wants his team to get going. At the age of 28, he will be looking to have his most productive Premier League season and Saturday was the ideal start.
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