France's Adrian Mannarino, a five-set victor over Daniil Medvedev, awaits in round four.
Federer has been in imperious mood in pursuit of his ninth Wimbledon crown, while Williams is rounding into form just as the seven-time champion's rivals have collapsed all around her.
Defending champion Roger Federer has reached the Wimbledon quarter-finals without dropping a set after he outclassed France's Adrian Mannarino.
Federer after winning his second round match at Wimbledon.
The Czech faces Dutch 20th seed Kiki Bertens, who stunned five-time Wimbledon victor Venus in the third round.
Switzerland´s Roger Federer celebrates after beating France´s Adrian Mannarino 6-0, 7-5, 6-4 in their men´s singles fourth round match on the seventh day of the 2018 Wimbledon Championships. I know that Phil Brook, the chairman right now, he believes in strict tradition, going back to the '50s, '60s.
She is the fourth former women's champion to get knocked out, joining Maria Sharapova, Petra Kvitova and last year's victor Garbine Muguruza. Williams will follow Federer at Centre Court, and she plays 120th-ranked qualifier Evgeniya Rodina of Russian Federation.
North Korea says U.S. are like 'gangsters' after 'regrettable' nuclear talks
He said he is "hopeful" there will be a "path forward" in negotiations with North Korea. The diplomatic disconnect makes it clear that the nations are not on the same page.
The status quo has been challenged like never before in the women's singles, with nine of the top 10 seeds crashing out before the Wimbledon last 16 for the first time in the Open area.
The 36-year-old faces Russian qualifier - and fellow mother - Evgeniya Rodina in the last 16.
So while tennis fans around the world start dreaming, hoping and longing that the two most successful players on planet tennis will renew their rivalry on the sport's greatest stage, there is one person who is definitely not keen on the idea.
Keys also came up short with a comeback attempt after fighting back from a set and two breaks down, losing 7-5, 5-7, 6-4.
The Spaniard, who has 17 grand slam wins in total, broke 19-year-old De Minaur twice in the second set and surged to a 4-2 lead in the third.
In the men's draw, third seed Marin Cilic, fourth seed Alexander Zverev and sixth seed Grigor Dimitrov have all fallen.
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